Abstract

Tablets are widely used due to the advantages like easy in administration, compactness, and dosage precision and economical. As this much advantages, the main and important part plays by the disintegrate in tablet. The release of the drug is totally depends on the disintegrants. Mostly in tablet formulation, the starch is widely used as a disintegrant with ideal properties like strong adhesiveness, thickening, strong gelling, swelling, and foaming properties. As this much of ideal properties but some properties like poor flow, less compressibility, and compatibility. In the present study pregelatinized starch was employed as a disintegrating agent in Diclofenac and Paracetamol tablet. The prepared starch was evaluated for angle of repose, bulk density, tapped density, Carr’s compressibility index, Hausner’s ratio. The prepared tablets were evaluated for thickness, drug content, weight variation, and friability and disintegration time and dissolution profile. Batches of tablets containing an equivalent concentration of sodium starch glycolate were employed as standard. From this, we concluded that as a disintegrant pregelatinized starch showed comparable results in Diclofenac and Paracetamol tablets with the standard.

Key words: Diclofenac, Paracetamol, pregelatinized starch, sodium starch glycolate