Objective: To evaluate the effects of the antiemetic drugs palonosetron and ramosetron, mixed with opioid-based intravenous patient-controlled analgesia (IV-PCA) regimen on postoperative nausea and vomiting (PONV).
Methodology: Patients were randomly allocated to three groups. Palonosetron (0.075 mg) was administered intravenously to all patients before anesthetic induction, and a 100-ml IV-PCA infusion, which contained 20 mcg/kg of fentanyl with placebo (normal saline) in group 1, ramosetron (0.3 mg) in group 2, and palonosetron (0.075 mg) in group 3 was started at the end of surgery. PONV, postoperative pain, and adverse effects were assessed.
Results: The incidence of postoperative nausea at PACU was lower in group 2 than in group 1 (5.6% vs 33.3%, p
Key words: 5-HT3 receptor antagonist, opioid, intravenous patient-controlled analgesia.
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