Role of Felodipine in Reduction of intimal Hyperplasia
Jehat Kutlay, Semih Aydıntuğ, Ergün Erdem, Uğur Kuşbaşoğlu, İbrahim Ceylan.
Abstract
One of the factors which decrease the long term success of peripheric vascular surgery is postoperative intimal hy¬perplasia in graft. There are a lot of literature on which aspirin, other non-steroid antiinflammatory drugs, dypridamole, heparin, converting enzym inhibitors, eicosopentanoik acid and calcium channel blockers that can be used for inhibi¬tion of graft intimal hyperplasia. In this report we tried to show the inhibition effect of felodipin (PLEN DIL) which is an se¬lective peripheric calcuim channal blockers on dogs that received autogenous vein bypass. We concluded that felodi¬pin can be used in early treatment ot venoarteriel reconstructive surgery to inhibit intimal hyperplasia.
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