Background: Hepatitis C virus (HCV) infection still maintains its importance since it is one of the most important causes of liver cirrhosis and hepatocellular carcinoma. Our hospital, located in Istanbul, which is the 10th most crowded city in the world, has a patient cohort where epidemiological change can be observed due to its deep-rooted history and serving people of different nations in terms of settlement. Main aim in this study is to evaluate the change in HCV epidemiology in our country over the years. Methods: Patients over the age of 18, whose HCV-RNA was positive between January 2001 and January 2021 were evaluated. Results: 1166 patients whose HCV genotype was determined were evaluated. The mean age of the population is 52 ± 14.75 years, 83.53% of all patients was infected with genotype 1 (GT1), 8.23% with GT3, 5.83% with GT2, 2.23% with GT4 and 0.17% of them with GT5. While the GT1 rate decreased in patients over the years, an increase was found in other GTs. GT1 and GT2 were more common in females (p
Key words: Hepatitis C, genotype, distribution, migration
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