Background: Intrauterine insemination (IUI) is one of the assisted reproductive techniques widely used in infertility treatment. This must be done at a specific time, and progesterone plays an important role in the implantation process, a prerequisite for embryonic attachment and invasion. This study aimed to evaluate the relationship between progesterone levels on the day of human chorionic gonadotropin (hCG) injection in the IUI cycle and fertility.
Methods: In this cross-sectional descriptive study, patients referred to the Infertility Center of Ardabil University of Medical Sciences for IUI during 2019-2020 were included. The pattern of the menstrual cycle, history of medical or surgical diseases, history of dyspareunia, number of previous IUIs, causes of infertility, and duration of infertility were entered in the relevant checklists. On the day of the hCG injection, a blood sample was taken, and the level of progesterone and estrogen were measured and evaluated.
Results: A total of 85 patients were included in the study. The IUI result was negative in 67 (78.8%) patients. The mean total IUI history of patients was 1.71 ± 0.8 years. The mean duration of infertility was 35.11 ± 18.31 months. The highest fertility rate was observed in the serum level of 1.21-1.6 progesterone. The mean serum level of estradiol was 816.46 ± 651.00 months.
Conclusion: The results of this study showed that the highest fertility rate was observed in the serum level of 1.21-1.6 progesterone in the IUI cycle.
Key words: Progesterone, IUI, human chorionic gonadotropin.
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