Abstract

Context: Present study is one of very few single largest single-centre studies in India of more than 1000 patients which provides multifactorial analysis of 15 factors across three distinct age-groups viz., COVID 19 patients of three different age groups, viz., young ( 18-34 years), middle-age (35-64 years), old ( more than 64 years) and their correlation with severity of disease and outcome during second wave of Covid-19.
Method and Material: Data of 1034 patients ( study-period:1st January to 31st May 2021) was retrieved and its multifactorial analysis carried out as regards clinical, biochemical and parameters, outcome and severity.
Results: Number of young, middle aged and old patients were 93 (8.99%), 550 (53.19%) , and 391 (37.81%) respectively. There was significant association between: age and severity, age and outcome. There was significant association between Total WBC counts, Sodium, D Dimer, CRP, S.Ferritin, S.LDH, Total bilirubin, S.Urea and Albumin and severity except: S.Sodium and Total WBC count (not associated with severity in young age group). There was significant association between Total WBC counts, D Dimer, S.Ferritin, S.LDH, S.Sodium, S.Albumin and S.Urea and outcome except: S.Ferritin, S.LDH and Total WBC counts were not associated with outcome in young.S.LDH> 234, Sodium >145, S.Ferritin >292, S.Urea >40 and Total leucocyte counts >11,000 were statistically significant in association with outcome.
Conclusion: Apart from age, elevated CRP, LDH and S. Sodium , S.Ferritin, Bl.Urea and Total leucocyte count are statistically significantly associated with severity and outcome.

Key words: COVID 19, Age, Comorbidities, Severity, Outcome