Abstract

Biodegradable poly (lactic acid) films containing Lapatinib were prepared by spreading polymer / Lapatinib solution on the non-solvent surface. Different drug loading polymer films can be obtained by controlling the weight ratios of drug and polymer. The synthesized Lapatinib loaded PLA films were evaluated by different parameters such as drug loading, encapsulation efficiency, surface morphology, differential scanning calorimetry, powder X-ray diffractometry and In vitro drug release kinetics. Various combinations of the polymer-drug weight ratios were used to achieve In vitro release of drug over a period of 30-35 days, with initial burst release < 25% and a steady release rate over the entire period of release. Furthermore the drug release rate of the film could be controlled by the drug loading content and pH of the release medium. Our results suggest that these Lapatinib loaded PLA film formulations could constitute a promising approach for the controlled drug delivery applications. This is the first study which shows the in-vitro release profile of Lapatinib using a polymeric delivery system.

Key words: poly (lactic acid), Lapatinib, films, biodegradable, controlled release.