Aim: The present study investigates synergistic effect of combination treatment of lycopene, quercetin and poloxamer188 in 3-nitropropionic acid induced Huntington's disease.
Materials and Methods: Anxiety and depression were induced in male Wistar rat by intraperitoneal administration of 3-nitropropionic acid (10 mg/kg) for 14 days. Body weight was assessed on day 1, 7 and 14 whereas locomotion, anxiety and depression were assessed at the end of the experiment.
Results: Administration of 3-nitropropionic acid induces Huntington disease like symptoms and produced significant decrease in body weight on day 7 (P
Key words: Huntington disease, 3-Nitropropionic acid, Lycopene, Quercetin
|
