Photostability of nifedipine in monolaurin solid matrix and micellar solution
Mallory Tough, Abebe Mengesha.
Abstract
The purpose of this study is to evaluate the photostability of nifedipine (NIF) in solid monolaurin (ML)-based matrix and the micellar solutions thereof. NIF loaded-ML matrices at concentrations of 1:1, 1:4 and 1:9 w/w were prepared using a fusion-high shear homogenization method and characterized using differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The absence of an endothermic melting peak at 173° C in the 1:4 and 1:9 w/w NIF-ML matrices indicates that NIF is in an amorphous state. The 1:1 w/w NIF-ML matrix showed an endothermic peak at 154° C indicating the transformation of NIF into polymorph III. Stability-indicating HPLC method was developed and validated to quantify NIF and its degradation product. Photoexposed 1:1, 1:4 and 1:9 w/w NIF-ML matrices exhibited 2.1, 4.6 and 17 fold slower first-order degradation rates as compared to the NIF powder. After 24 days of exposure, the percent drug remaining in the 1:9 w/w NIF-ML matrix was 85% as compared to only 5% in pure NIF powder. The micellar solutions exhibited 7-fold slower degradation kinetics than the aqueous solution. The results of this study indicate that the stability of nifedipine can be improved by formulation into monoglycerides matrix.
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