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Original Article

J App Pharm Sci. 2015; 5(5): 075-079


Antithrombotic activities of Newbouldia laevis (P. Beauv) seem. ex Bureau leaves

Chinaka O. Nwaehujor, Rita I. Udegbunam, Julius O. Ode, Stella A. Madubuike.



Abstract
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The study evaluated anticoagulant properties of the methanol extract of Newbouldia laevis leaves using blood clotting time, bleeding time and thrombin-induced clotting assay as standard procedures. Oral acute toxicity studies showed that the extract had a high safety margin, up to 2000 mg/kg in Wistar rats. The methanol leaf extract of N. laevis significantly (p

Key words: Anticoagulant, Newbouldia laevis, Heparin, Ethylenediaminetetraacetic (EDTA), Thrombosis, Thrombin-induced clotting time

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