Aim: Despite intensive research, liver diseases represent a significant health problem and current medicine does not offer a substance able to significantly inhibit the hepatotoxicity leading to various stages of liver disease. Based on our previously published studies showing the protective effects of a glucan-humic acid combination, we focused on the hypothesis that combination of these two natural molecules can offer prophylactic protection against experimentally induced hepatotoxicity. Methods: lipopolysaccharide (LPS), carbon tetrachloride (CCl4) and ethanol were used to experimentally damage the liver. Levels of aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA), known to correspond to the liver damage, were assayed. Results: Using three different hepatotoxins, we found that in all cases, some samples of humic acid and most of all the glucan-humic acid combination, offer strong protection against liver damage. Conclusion: glucan-humic acid combination is a promising agent for use in liver protection.
Key words: humic acid; glucan; liver; protection; enzymes;
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