Abstract

AIM: In this study, we determined the antimicrobial susceptibility of Staphylococcus aureus strains lead to nosocomial infections in a three year period including 2006, 2007 and 2008 in a 1000-bed teaching hospital. We aimed to help clinicians while choosing the appropriate antimicrobial agent in empiric theraphy and to gain epidemiological data in addition to other regional studies.
METHOD: We included 408 S.aureus strains, 216 (52.9%) from surgical and 192 (47.1%) from medical wards. Susceptibility of isolates to methicillin and other 12 antimicrobial agents used for treatment was determined by using Kirby-Bauer disk diffusion method according to “Clinical and Laboratory Standards Institute” criteria.
RESULTS: Ratio of S.aureus to all isolated strains from inpatients was 6.3% for 2006, 6.2% for 2007, 8.2% for 2008. Among all S.aureus isolates, 45.6% (186/408) were resistant to methicillin and ratio of methicillin resistant S.aureus (MRSA) was 56.6% for 2006, 39.3% for 2007, 42.0% for 2008. All tested antimicrobials except trimethoprim/sulfamethoxazole exhibited higher resistance rates in methicillin resistant S.aureus strains compared to methicillin susceptible S.aureus.
CONCLUSION: Enhanced surveillance and rational infection control measures should be adopted by healthcare institutions to address infections especially caused by MRSA in health-care settings. We concluded that antimicrobial susceptibility patterns of isolates from clinical materials, specific microbial profiles of hospitals and well coordinated practice between clinicians and laboratory stuff are powerful tools in guiding empirical treatment as well as pathogen spesific treatment of infectious diseases.
*Bu çalışma, XXXIII. Türk Mikrobiyoloji Kongresi (21-25 Ekim 2008, Bodrum)’nde sunulmuştur.

Key words: Inpatients, Staphylococcus aureus, Drug Resistance, Bacterial, Methicillin Resistance

Article Language: Turkish English