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Original Research

RMJ. 2025; 50(1): 87-91


Impact of fluid consumption on serum copeptin levels among diabetes mellitus patients with progressive diabetic nephropathy

Tooba Noor, Adeena Jamil, Hina Badar Afnan, Zareen Kiran, Muhammad Tassaduq Khan, Farina Hanif.



Abstract
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Objective: To investigate the relationship of copeptin, a surrogate marker of vasopressin with varying fluid intake among individuals with progressive stages of diabetic nephropathy.
Methodology: This retrospective analytical cross-sectional study was conducted on prediabetes, DM without nephropathy and DM with nephropathy and compared with controls. Biochemical tests and 24hr fluid intake history was taken. Sandwich based Enzyme-Linked Immunosorbent Assay (ELISA) was used to measure serum copeptin levels.
Results: We found that 47.5% participants were consuming

Key words: Arginine vasopressin, copeptin, fluid, nephropathy, osmolarity, diabetes mellitus.





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03040506070809101112
2025

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