Aim: To compare the effect of dexmedetomidine on providing controlled hypotension and surgical field quality,
liver and kidney function in middle ear microsurgery, with nitroglycerine.
Material and Method: Patients were divided into two groups after anesthetic induction with thiopental (5-7 mg. kg-
1), fentanyl (1 μg. kg-1), and vecuronium (0.1 mg. kg-1). In dexmedetomidine group (n=20), following the loading
dose of 1 μg. kg-1 (10 min), infusion was applied with a dose of 0.1-0.7 μg.kg-1.h-1. In nitroglycerine group (n=20),
infusion of nitroglycerine was applied with a dose of 0.25-1 μg.kg-1.min-1. Drug doses were titrated to maintain the
mean arterial pressure (MAP) at 65-75 mmHg. Anesthesia was maintained with 4-6 % desflurane and 60% oxygenair
mixture. During controlled hypotension, arterial blood gas analysis was examined. For the measurement of AST,
ALT, BUN and creatinine, blood samples were obtained before and after surgery and on postoperative third day.
Results: Fifteen minutes after controlled hypotension and immediately after the extubation, MAP and HR were
higher in nitroglycerine group (95.15 ±16.88 and 96.10 ± 22.76, respectively) when compared with
dexmedetomidine group (84.90 ± 14.26 and 82.65 ± 18.82, respectively). In dexmedetomidine group, 15 min after
controlled hypotension, MAP was higher compared to the value previous to induction (p
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