Abstract

 

Objective: The study was planned to determine whether or not, second trimester maternal serum levels of ß2-

microglobulin could be used to predict subsequent devolopment of preeclampsia.

Study design: Serum ß2-microglobulin levels of 7 nulliparous and 8 multiparous women with normotensive were

determined nephelometrically. Blood samples were collected between 18 and 26 weeks gestation and those cases

were followed up prospectively for subsequent devolopment of preeclampsia.

Results: Mean maternal serum ß2-microglobulin levels of 15 normotensive pregnant patients were found 1.00±0.10

mg /L. Fifteen normotensive women were followed up prospectively, two of them (13.3%) preeclampsia developed

and 13 women remained normotensive (86.7%) throughout pregnancy. No difference betw een maternal serum ß2-

microglobulin levels of two patients with preeclampsia and 13 patients who remained normotensive during gestation

was found (1.01±0.10mg/L vs 1.00±0.11 mg/L, p