This review is about clinical pharmacology of histamine H2-receptor antagonists and their prophylactic and therapeutic effects in peptic ulser disease, Zollinger-Ellison Syndrome, gastroesophageal reflux and acute stress ulcers and erosions which are known asid-peptic disorders. H2-receptor blocker drugs (Cimetidine, Ranitidine, Famotidine, Nizatidine) using clinically shows similar effects when they are equipotent doses. Cimetidine and in a lesser extent ranitidine could interact many drugs by inhibiting metabolism of these drugs. However, famotidine and nizatidine interact with other drugs lesser than former drugs. If a therapy is planned with H2-blocker drugs, interactions with other drugs, safety and price of these drugs should be considered. [Journal of Turgut Özal Medical Center 1(1):53-64,1994].
Key Words : Histamine, H2-receptor blockers, clinical pharmacology
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