The effects of vitamin E and C combination on hyperbaric oxygen-induced lung toxicity in rats
Erkan KIBRISLI*, Erdal KARAÖZ**, Münire GÖKIRMAK***, Murat YAĞMURCA****, M. Kemal IRMAK****
.
Abstract
Objectives: We examined the histopathological changes in the respiratory system of the rats induced by hyperbaric oxygen (HBO) administration and the effects of vitamin E and C on these alterations.
Materials and Methods: Thirty adult rats were divided into three groups as control, HBO and HBO+Vit groups. Twenty animals in HBO and HBO+Vit groups were exposed to HBO on a daily basis for 45 days. Additionally, vitamin E and C were administered to the rats in the HB0+ Vit group intraperitoneally during HBO exposure.
Results: Histologic examination in HBO group demonstrated epithelial thickening in the trachea, increase in the thickness of alveolar septae, emphysema and mononuclear cell infiltration in lung tissue. Vitamin administration in addition to HBO seemed to reduce the negative effects of HBO on the trachea and lungs of the rats.
Conclusions: It is concluded that vitamin E and C have positive effect on limiting the tissue damage caused by HBO.
Key words: HBO, lung, trachea, anti oxidant treatment.
The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
We use cookies and other tracking technologies to work properly, to analyze our website traffic, and to understand where our visitors are coming from. More InfoGot It!
