Abstract

 


Many skin flaps have been defined for the reconstruction of skin defects. Distal flap necrosis is met as a serious problem especially while elevating long skin flaps. So many experimental and clinical studies have been done to prevent distal flap necrosis and to improve the survival of skin Haps. In this experimental study, the effect of an anti-inflammatory agent, namely etophenamate on skin Hap survival rates has been investigated. In Sprague-Dawiey rats, caudally based random pattern dorsal skin flap including pannicuius carnosus 3x10 cm in size were elevated and sutured back to its original place. In the control group, no pharmacological agent was given, and in the experimental group, etophenamate 10 mg/kg/day, IM, was administered for seven days postoperativeiy. On the seventh day, the surviving areas of the skin flaps were measured and the results were evaluated by Students t-test. The survival rates of skin flaps were found as % 83. 27 in the etophenamate and % 65.70 in the control group. It was found that etophenamate increased the survival rates of skin flaps, statistically significant, comparing to that of control group (p