In this study, 8 gallbladder carcinomas among 435 cholecystectomy specimens which were examined in the Pathology Department of İnönü University Medical School, between 1992 and 1996, were reviewed. In microscopic examination, three mucinous carcinomas, three well and one moderately differentiated adenocarcinomas and one adenosquamous cell carcinoma were seen. Dysplasia was detected in two cases adjacent to tumor tissues. Five cases had stage V, 1 had stage IV and, 2 had stage III tumors. Tumor cells were focally positive for Chromogranin-A in 2 adenocarcinomas and 2 mucinous carcinomas. Although it is reported that neuroendocrine differentiation has no effect on prognosis of gallbladder carcinoma, the number of Chromogranin-A positive cases was more common in advanced stage tumors in our study. [Journal of Turgut Özal Medical Center 1997;4(1):116-119]
Key Words: Gallbladder, carcinoma, neuroendocrine differentiation, dysplasia
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