Increased Populations of Neuroendocrine Cells in the Colon of Patients with Hirschprung?s Disease
Bülent Mızrak1, MD, Dr. Güngör Bayraktaroglu2, MD
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Abstract
The distribution of mucosal neuroendocrine (NE) cells in the colon from 21 patients with Hirschprung’s disease (HD) and from 4 controls were studied. Immunohistochemical stains were done out using antibodies against chromogranin A and neuron-specific enolase (NSE). Immunostaining with both antibodies gave similar results: immunoreactive cells significantly increased in the aganglionic bowel compared with ganglionic bowel and controls (p
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