Introduction: Multiple sclerosis (MS) is a chronic, progressive, inflammatory and demyelinating disease of the central nervous system that commonly affects young adults and which may lead to various physical disabilities. It has been reported that bipolar disorder is twice more common among MS patients compared to the normal population. The comorbidity of MS and bipolar disorder, which has not been sufficiently studied until now, is a relatively common state. A variety of mechanisms have been proposed to explain this comorbidity. It has been suggested that bipolar disorder in MS patients may be a sign of the disease, a concurrently diagnosed condition, or a side effect of the drugs (such as corticosteroids) used for therapeutic purposes.
Conclusion: The aim of this manuscript was to describe a case of multiple sclerosis that presented mixed state bipolar affective disorder as its initial sign, and to discuss this case in light of the literature.
Key words: Multiple sclerosis, bipolar affective disorder, mixed period.
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