This study explored the possibility of bleeding from peptic ulcer bleeding (PUB) in diabetic patients and to understand how diabetes might influence the outcomes of this condition. A thorough computerized search of relevant databases was carried out to locate research that met the inclusion criteria. A comprehensive search was conducted on PubMed, SCOPUS, Science Direct, Cochrane Library, and Web of Science to locate relevant material. The dataset comprised of 5 studies involving 27,263 participants, with 12,769 (46.8%) being males. Diabetes mellitus (DM) has been linked to a higher incidence of postoperative complications like PUB, especially in high-risk groups such as the elderly, hemodialysis users, and people with chronic renal disease. Although the association is less clear in the general population, studies consistently showed that diabetic patients with peptic ulcer complications, such as bleeding, experience higher short-term mortality rates. These findings highlighted the need for heightened clinical vigilance in managing peptic ulcer disease among diabetic individuals, especially those with comorbid conditions. Higher mortality and an increased risk of PUB are linked to DM, particularly in high-risk groups like those with chronic kidney disease or on hemodialysis. Although the link is less clear in the general population, diabetic patients with PUB face poorer outcomes. Early detection and preventive strategies in diabetic patients, especially those with comorbidities, are essential for reducing complications. More study is required to fully comprehend glycemic management in PUB risk.
Key words: Peptic ulcer bleeding, diabetes mellitus, gastrointestinal symptoms, association, systematic review
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