Abstract

Aim: We aimed to investigate the potential use of ischemia-modified albumin (IMA) as an indicator for oxidative stress in individuals with lower extremity peripheral vascular disease (PAD).
Material and Methods: This case-control study included 80 patients with lower extremity PAD as the study group and 80 individuals without PAD as the control group. Demographics, clinical characteristics, and laboratory data, including IMA, were compared among these groups.
Results: No notable differences were observed regarding the fundamental clinical characteristics among the groups. The study group exhibited a significantly higher median IMA level when compared to the control group. Receiver operating characteristic (ROC) curve analysis indicated that an IMA of 0.605 represented the optimal cut-off value, obtaining 87% sensitivity and 48% specificity.
Conclusion: This study suggests that IMA serves as a sensitive and practical biomarker for oxidative stress in patients with lower extremity PAD. However, further well-designed studies with larger patient participation are required in order to support the findings of this study and achieve more valuable scientific evidence.

Key words: Ischemia-modified albumin, biomarker, oxidative stress, lower extremity peripheral arterial disease