Abstract

Aim: Peripheral artery disease (PAD) can create a clinical picture ranging from pain to amputation. Additional diseases and lifestyle can increase the risk and level of the disease. Although the advancement of endovascular intervention technologies has increased the success rate of PAD treatments, comorbidities pose a risk for recurrence. Inflammation plays a role in the formation and recurrence of PAD. Neutrophil/Lymphocyte ratio (NLR) and Platelet/Lymphocyte ratio can be markers indicating a destructive, thrombogenic inflammatory response. The aim of this study is to evaluate the association between systemic inflammatory markers—specifically NLR and platelet-to-lymphocyte ratio (PLR)—and post-treatment recurrence in patients undergoing endovascular intervention for PAD, and to investigate the prognostic value of these biomarkers".
Material and Methods: Patients diagnosed with PAD who underwent endovascular intervention were included in this retrospective study. Demographic data, comorbidities, and laboratory markers (NLR and PLR) were recorded. Recurrence was assessed based on follow-up Doppler ultrasound findings. Data analysis was performed using SPSS version 22.
Results: Restenosis developed in 182 of 286 patients included in the study. Diabetes mellitus, hypertension, active smoking, critical ischemia, revascularization method and high post-procedure NLR PLR ratios were found to be statistically significantly associated with recurrence. Age and pre-procedure NLR PLR were not significantly associated with recurrence.
Conclusion: Endovascular revascularization methods, additional comorbid conditions and high NLR and PLR rates after the procedure are important factors causing recurrence, but larger sample groups and more studies are needed to investigate this situation.

Key words: Peripheral angioplasty, recurrence, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio