Currently, there are sufficient evidences that there is a strong correlation between inflammation and cancer. In this regard, some NSAIDs such as celecoxib, were studied for the treatment and prevention of colon cancer. We herein have synthesized some novel diphenylthiazole-amino acids conjugates and evaluated their anticancer activity against three cancer cell lines; MCF-7, HT-29 and A549 using MTT assay. Furthermore, their anti-inflammatory activity was evaluated in vivo using carrageenan-induce paw edema assay. Compound 8a bearing methylglycine moiety exhibited the highest anticancer and anti-inflammatory activities with IC50 between 0.6 µM and 4.0 µM and edema inhibition% between 80 and 84, respectively.
Key words: Diphenylthiazole; Amino acid; Anticancer; Anti-Inflammatory; NSAIDs
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