Abstract

Background and Aim: The rise in drug-resistant tuberculosis, particularly multidrug-resistant tuberculosis (MDR-TB) and rifampicin-resistant Mycobacterium tuberculosis (RR-MTB), presents significant challenges to tuberculosis control efforts as it complicates treatment and increases the risk of mortality. Early detection and appropriate management of RR-MTB are crucial for effective tuberculosis control. This study aimed to determine the prevalence of rifampicin resistant Mycobacterium tuberculosis (RR-MTB) among patients diagnosed with pulmonary tuberculosis.
Method: Two hundred and eighty-three sputum samples were collected from patients diagnosed with pulmonary TB from three general hospitals in Oyo State. The sputum samples were analyzed using the GeneXpert MTB/RIF assay to detect the presence of MTB and resistance to rifampicin. Data on demographic and clinical characteristics were also collected and analyzed using the Chi-Square test and ratio analysis, with a significance level set at p

Key words: Mycobacterium tuberculosis, Multidrug-resistant TB, Rifampicin resistance, GeneXpert MTB/RIF assay