Background:
Salmonella enterica serotype Typhi remains a major global health concern, particularly in regions with limited resources. Interleukins such as interleukin-5 and interleukin-23 are thought to play pivotal roles in shaping the host's immune defense against this pathogen, yet their precise contributions are not fully understood.
Aim:
This study aims to clarify how interleukin (IL)-5 and interleukin (IL)-23 interact within the human immune response during Typhi infection and whether they can serve as useful immunological markers.
Methods:
Blood samples were collected from patients with confirmed typhoid and healthy controls. Cytokine expression levels were analyzed using standard immunoassay techniques and molecular detection methods.
Results:
Both interleukin (IL)-5 and IL-23 were significantly upregulated in infected individuals compared to healthy controls (p < 0.05). Their elevated levels play a potential role in immune pathway modulation that could influence disease progression or recovery.
Conclusion:
Understanding how IL-5 and IL-23 contribute to host defense may open new avenues for developing better diagnostic tools and therapeutic targets for typhoid fever.
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