Novel functionalized pyrimidine, thioxopyrimidine, iminopyrimidine derivatives and their derived bicyclic thiazolopyrimidine compounds were synthesized. The substituted arylidine derivatives of the thiazolopyrimidine compounds were also prepared. Glycosylation of the thiopyrimidine derivative resulted in formation of the acetylated thioglycosides which were deacetylated to the free hydroxy thioglycosides. The synthesized compounds were studied for their cytotoxic activity against three cell lines namely; HepG-2, PC-3 and HCT-116 cell lines. Compounds 7c, 8a and 12a showed high activity against PC-3 cancer cells while compounds 11b and 12a revealed higher activity against HCT-116 cell line.
Key words: Key words: Pyrimidines, Thiazolopyrimidines, Thioglycosides, Cytotoxic, HCT-116, PC-3
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