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Original Article



Therapeutic Potential of Ethanolic and Aqueous Fractions of Cassia alata (Leguminosae) in Reducing Phenotypic, Immunological and Tissue Damage in a Rat Model Atopic Dermatitis

Habiba Zaitune,Che Gwendoline,Oumar Mahamat,Tume Christopher.



Abstract
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Background: Atopic dermatitis (AD) is usually considered as chronic inflammatory skin condition. The present study aimed to present the actions of fractions of Cassia alata supporting its use in the treatment of atopic dermatitis.
Methods: The effects of fractions of C. alata in the treatment of atopic dermatitis which is induced by the topical application of 2, 4-dinitrochlorobenezene (DNCB) were assessed in rats. After topical application, the presence of erythema, ear thickness and scratching frequency were recorded. The plasma levels of IgE, TNF-α, IL-1β, IL-4, IL-5 and IL-13 were recorded using ELISA kits.
Results: Results of this study showed that the ethanolic and aqueous fractions significantly (p

Key words: Atopic dermatitis, Cassia alata; Cytokines; Immunoglobulin E

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