Semicarbazide (SE) is a known food additive that can be found both in nature and in manufactured glass containers. Alas, it has deleterious effects on both animals and human. In this study, novel results are presented on the effect of SE on testicular tissue in juvenile male rats and the counter-effect of natural plant extract, i.e., turmeric (TU), in ameliorating such effect. Male juvenile rats were divided into four experimental groups: control group, TU group, SE group and SE+TU group. In addition to the histological examination, blood total triiodothyronine (T3), total thyroxine (T4), testosterone levels, histological picture of testis as well as the expression of caspase-3 and Bax were investigated. Administration of SE caused many damages including weight loss, decrease in testes weight and histopathological damages in the testicular tissue. In contrast, the combined administration of SE+TU restored the T3, T4 and testosterone levels as well as improved the histological testicular profile. Therefore, it is concluded that TU was able to mitigate the deleterious effects of SE.
Key words: Bax; Caspase-3; Juvenile rats; Semicarbazide; Testis; Turmeric.
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