Abstract

Abnormal uterine bleeding (AUB) is an important clinical concern among reproductive-aged women, and is usually associated with benign or malignant gynecologic conditions. The aim of the present study is to determine the clinical spectrum of AUB patients and to investigate the relationship between indications and histopathological results of AUB patients undergoing endometrial sampling. A total of 625 female patients who presented to Canakkale Onsekiz Mart University Hospital between October 2013 and October 2017 due to non-obstetric gynecological causes and underwent endometrial sampling included in the present study. The median age of patients was 46 years (min-max: 28-90 years) and the most common clinical presentation was represented by menometrorrhagia/menorrhagia (50.4%) followed by postmenopausal bleeding (38.6%), and myoma uteri (9.3%). Endometrial sampling evaluation revealed various patterns on histopathology. The most common encountered diagnosis was proliferative-secretory endometrium (41.3%), followed by endometrial polyp (20.2%) and simple hyperplasia without atypia (9.6%). Endometrial cancer was observed more frequently in the post-menopausal bleeding. AUB which often prevails as an important and common gynecological ailment in perimenopausal women is commonly due to dysfunctional in origin. Therefore routine endometrial biopsy should not be an initial clinical investigation for menorrhagia. It should be preferred in case of persistent menorrhagia in conjunction with presence of additional risk factors.

Key words: Abnormal uterine bleeding, endometrial sampling, histopathologyogy