Abstract

Acrylamide (ACR) is a widely encountered contaminant in food and an industrial chemical that predominantly harms various organs by triggering oxidative stress. The present research was designed to evaluate the safeguarding roles of boric acid (BA) and sesamol (SML) against the toxicity elicited by ACR in a rat model through the assessment of oxidant-antioxidant, inflammatory, and biochemical indices. Experimental rats were randomized into six different groups (n = 6 per group). Group I: (control) was given distilled water intraperitoneally and orally once a day, Group II: BA group (10mg/kg b.wt., i.p. injection for 11 continuous days), Group III: SML group (50 mg/kg b.wt., i.p. injection for 11 days), Group IV: ACR group (38.27 mg/kg b.wt., oral) and Group V: ACR + BA group, Group VI: ACR + SML group. The exposure to ACR for 11 uninterrupted days induced marked toxicity, which was evidenced by raised malondialdehyde (MDA), diminished reduced glutathione (GSH), and elevated inflammatory markers in serum. Furthermore, ACR significantly increased the activities of serum transaminases, raised blood urea nitrogen (BUN) and serum creatinine, and disturbed serum biochemical indices, including total protein, albumin, and lipid profile in serum. In contrast, the administration of BA and SML notably improved these alterations and reverted serological parameters to normal. These findings accentuate that BA and SML can lessen the harmful effects linked to acrylamide exposure.

Key words: hepatotoxicity; nephrotoxicity; acrylamide; boric acid; sesamol