Abstract

There has been a recent appeal for creating new excipients that could be employed as disintegrants. Because different disintegrating agents can assist in increasing the moisture penetration and dispersion of the tablet matrix, tablet disintegration has recently gained much attention as a crucial step in obtaining rapid drug release. In order to assist in breaking up tablets and capsules into smaller pieces. In order to speed up the disintegration of medications that are not highly water-soluble, natural polymers such as gums, mucilage, and dried fruits are employed. Compared to synthetic disintegrants, natural ones are safer and more affordable. The calming impact, biocompatibility, availability, low cost, and non-irritating nature of natural excipients set them apart from semi-synthetic and synthetic excipients. They are also less costly and more widely accessible. Consequently, an effort has been made to investigate the many natural disintegrants employed in the formulation and development of pharmaceuticals in the current review.

Key words: Excipients, Plant, Natural Disintegrants, Natural superdisintegrants, formulation.