Abstract

In the present article the effects of different reaction conditions on the synthetic method of isopropyl chloroacetate have been reviewed. Different catalysts that consist of inorganic salt like (Ce(SO4)2∙4H2O and NaHSO4) and PCl3 have also been introduced. The reaction conditions include the reaction time, the molar ratio of chloroacetic acid to isopropanol, the amount of the catalyst and the number of reusable catalyst. The optimized reaction time, the molar ratio of chloroacetic acid to isopropanol and the amount of the catalyst are beneficial to improve the yield of isopropyl chloroacetate.

Key words: reaction conditions; synthesizing; isopropyl chloroacetate