Abstract

Objective: To explore noninvasive diagnostic criteria for advanced stage ovarian cancer with CA 125 >1000 IU/ml and unilateral/bilateral complex adnexal mass on CT scan, in whom upfront bulk reducing surgery was not possible.
Methodology: This retrospective observational study was conducted at Oncology Department, FFH, Rawalpindi from 01/01/2010 till 31/12/2020. Fifty-one patients met the inclusion criteria for analysis.
Results: All patient with raised CA 125 and complex adnexal masses detected on CT scan had histological evidence of malignancy. Diagnosis was confirmed by either fluid cytology, FNAC of ovarian lesion, histopathology and immunohistochemistry in 33.3%, 2%, 54.9% and 9.8% patients, respectively. Findings of raised level of CA 125 with complex adnexal mass on CT scan correlated well with histological diagnosis of ovarian carcinoma in 100% of the cases.
Conclusion: CT scan findings and CA 125 level >1000 correlated well in predicting the diagnosis of ovarian epithelial carcinoma in 100% of cases. This diagnostic model can be extremely useful particularly in resource constraint countries.

Key words: CA125, ovarian cancer, complex adnexal mass.