Abstract

An efficient and greener one pot method has been developed for the synthesis of isoindolo[2,1-a]quinazolines using 2-morpholinoethane
sulfonic acid as a water soluble green catalyst at ambient temperature and excellent yield of product. The synergetic effect of 2-
morpholineethane sulfonic acid and ultrasound irradiation process has been also discussed.

Key words: 2-morpholinoethanesulfonic acid, ultrasound, multi-component reactions, 2-carboxybenzaldehyde, isatoic anhydride, aromatic amines, benzylamine