Abstract

A convenient and environmentally benign silica-supported 2,4,6-trichloro-1,3,5-triazine (Silica-TCT) catalyzed Hantzsch multicomponent
reaction has been shown between aldehydes, 1,3-dicarbonyl compounds and ammonium acetate in combination with stirring at room
temperature under solvent-free condition to yield 1,4-dihydropyridines. Use of Silica-TCT catalyst gives several advantages in terms of
simple reaction procedure, no need of organic solvent, mild reaction conditions giving quantitative yield of desired product.

Key words: 1,4-dihydropyridines, silica-TCT, ethyl acetoacetate, substituted benzaldehyde, solvent-free