A trend analysis of Sars-Cov-2 anti-nucleocapsid IgG antibodies with a recommendation of the cut-off classification to identify naïve, vaccinated, and infected cases

Med-Science. 2022; 11(4): 1534-40

doi: 10.5455/medscience.2022.07.153

Serhat Uysal, Kutbeddin Demirdag, Mesut Batur, Safak Ozer Balin, Mehmet Ali Asan, Ayse Sagmak Tartar, Ayhan Akbulut.

Abstract
Determination of the vaccination’s effect on immune responses with the emergence of the Sars-Cov-2 pandemic become an important issue. This study aimed to evaluate the response of the anti-nucleocapsid IgG (anti-N IgG) index in naïve, vaccinated, or infected cases, in addition to suggesting ‘How to distinguish between vaccinated versus infected cases via anti-N IgG?’. Anti-N levels of the naïve [0.03 (0.02–0.06)], vaccinated [0.7 (0.2–1.96)], and infected [3.07 (1.44–5.2)] groups were statistically different (p Key words: COVID-19, anti-nucleocapsid IgG, ınactive vaccine, naïve, SARS-Cov-2, vaccination, serology