Abstract

A new series of 2,3-disubstituted quinazolin-4(3H)-one derivatives was synthesized via nucleophilic attack at C(2)of the corresponding key
starting material 2-(4-bromophenyl)-4H-3,1-benzoxazin-4-one (Scheme 5). The reaction proceeded via amidinium salt formation (Scheme
3) rather than via an N-acyl anthranilamide. The structure of the prepared compounds were elucidated by physical and spectral data like FTIR, 1H-NMR, and mass spectroscopy.

Key words: Benzoxazin-4-one, 2,3-disubstituted quinazolin-4-one, glycine